降脂丸治疗高脂血症54例

目的观察降脂丸对血脂的影响及其抗氧化作用。方法54例单纯高脂血症患者服用降脂丸治疗，共4个疗程（56d）。比较治疗前后血脂、肝肾功能、抗氧化指标及不良反应变化。结果治疗后患者肝肾功能及肌酶无明显变化（P〉0．05），总胆固醇（TC）、低密度脂蛋白（LDL）显著降低（P〈0．05）；丙二醛（MDA）明显降低（P〈0．05），而谷胱甘肽过氧化物酶（GSH-PX）活性显著提高（P〈0．05）。结论降脂丸有较好的降血脂和抗氧化作用。     

复方益母草合剂的质量标准研究

目的建立复方益母草合剂的质量标准。方法用薄层色谱法对制剂中益母草、当归、甘草进行鉴别,以HPLC法对组方阿魏酸进行含量测定。结果薄层鉴别斑点清晰,阴性对照无干扰。阿魏酸的线性范围为0.512～2.560μg(r=0.9998),平均回收率为99.02%。结论本标准的制定可为该制剂的质量控制提供依据。     

大黄虫合剂对免疫低下及正常小鼠T细胞亚群水平的影响

目的：探讨大黄虫合剂对免疫功能的调节作用。方法：选取昆明种小鼠100只,随机分为非免疫抑制组（正常小鼠）和免疫抑制组,每组各50只。正常小鼠两次随机分为正常对照组、中药对照组（六味地黄组）、西药对照组（卡介苗多糖组）及大黄虫合剂大、小剂量组;免疫抑制组腹腔注射环磷酰胺复制疫低下小鼠,然后分为模型对照组、环＋中药对照组、环＋西药对照组及环＋大黄虫合剂大、小剂量组。各组药物干预后处死小鼠摘取脾脏,用免疫组化的方法检测T细胞亚群含量。结果：大黄虫合剂能显著提高正常小鼠和免疫功能低下小鼠CD4^＋、CD8^＋的百分率及CD4^＋/CD8^＋比值（P〈0.05）。结论：大黄虫合剂能够通过增强小鼠T淋巴细胞的免疫水平,显著提高机体的免疫功能。     

三仁化湿合剂治疗慢性活动性乙型肝炎120例临床研究

目的：观察三仁化湿合剂治疗慢性活动性乙型肝炎的临床疗效。方法240例患者随机分为两组，对照组在西医常规治疗的基础上加服护肝片治疗；治疗组在西医常规治疗基础上加服三仁化湿合剂治疗。结果：治疗组在改善肝功能、缓解临床症状方面与对照组比较，有显著性差异（P〈005）：结论：三仁化湿舍剂具有较强的保护肝细胞和改善肝功能作用。     

Population Heterogeneity in the Salience of Multiple Risk Factors for Adolescent Delinquency

PurposeTo present mixture regression analysis as an alternative to more standard regression analysis for predicting adolescent delinquency. We demonstrate how mixture regression analysis allows for the identification of population subgroups defined by the salience of multiple risk factors.MethodsWe identified population subgroups (i.e., latent classes) of individuals based on their coefficients in a regression model predicting adolescent delinquency from eight previously established risk indices drawn from the community, school, family, peer, and individual levels. The study included N = 37,763 10th-grade adolescents who participated in the Communities That Care Youth Survey. Standard, zero-inflated, and mixture Poisson and negative binomial regression models were considered.ResultsStandard and mixture negative binomial regression models were selected as optimal. The five-class regression model was interpreted based on the class-specific regression coefficients, indicating that risk factors had varying salience across classes of adolescents.ConclusionsStandard regression showed that all risk factors were significantly associated with delinquency. Mixture regression provided more nuanced information, suggesting a unique set of risk factors that were salient for different subgroups of adolescents. Implications for the design of subgroup-specific interventions are discussed.     

Mixture effects of nonylphenol and di-n-butyl phthalate (monobutyl phthalate) on the tight junctions between Sertoli cells in male rats in vitro and in vivo

The estrogenic chemical nonylphenol (NP) and the antiandrogenic agent di-n-butyl phthalate (DBP) are regarded as widespread environmental endocrine disruptors (EEDs) which at high doses in some species of laboratory animals have adverse effects on male reproduction and development. Given the ubiquitous coexistence of various classes of EEDs in the environment, their combined effects warrant investigation. In this study, we attempted to clarify the interactions of NP and DBP on tight junctions (TJs) between rat Sertoli cells. In the in vitro experiment, monobutyl phthalate (MBP), the active metabolite of DBP, was used instead of DBP. Sertoli cells were isolated from Sprague-Dawley rats, and treated with NP and MBP, singly or combined. The morphology of Sertoli cells, and structure and functionality of TJs were measured. In the in vivo experiment, rats were gavaged on postnatal day 23–35 with a single or combined NP and DBP treatment. Testicular weight and morphology of TJs were recorded. These data indicated that NP and DBP/MBP, either in single or in combination, induced the structural and function changes of Sertoli cell tight junctions, both in vivo and in vitro. The combined effect on the regulation of TJ proteins at both the protein and gene levels was correlated to the effect exerted by NP, suggesting that the structure and function of Sertoli cells were more sensitive to exposure to NP than MBP.     

桑麻合剂治疗小儿支气管炎临床研究

目的：研究桑麻合剂用于治疗小儿支气管炎的临床效果.方法：选取100例支气管炎患儿,随机分为实验组和对照组各50例.两组均给予常规治疗,实验组在常规治疗的基础上采用桑麻合剂进行治疗,对照组在常规治疗的基础上服用盐酸氨溴索,观察比较两组患者的治疗效果及不良反应.结果：实验组有效率为96.0％,明显优于对照组的76.0％（P＜0.05）;实验组复发率为4.0％,明显低于对照组的20.0％ （P＜0.05）;服用药物过程中两组患者均未出现不良反应.结论：桑麻合剂用于治疗小儿支气管炎能取得理想的临床效果,值得临床推广应用.     

优选清肺止咳合剂的提取和浓缩工艺

目的优选清肺止咳合剂的提取和浓缩工艺。方法以连翘苷的含量为评价指标,以加水量、提取时间、提取次数为考察因素,采用正交实验优选其提取工艺;并对比研究减压浓缩和常压浓缩对连翘苷转移率的影响。结果优选的提取工艺为加10倍量水,煎煮3次,每次煎煮1h;两种浓缩方式对连翘苷的含量无显著性影响。结论该工艺合理可行,可有效地用于清肺止咳合剂的生产。     

“降脂膏”贴脐治疗非酒精性单纯性脂肪肝的疗效观察

目的:观察降脂膏贴脐治疗非酒精性单纯性脂肪肝的疗效。方法:将符合非酒精性单纯性脂肪肝诊断的36例病人,全部采用降脂膏贴脐疗法,治疗3个疗程后采用"疗效标准"判定疗效。结果:36例中,临床治愈7例,占19.4%;显效19例,占52.8%;有效8例,占22.2%;总有效率为94.4%,且血清TC,TG较治疗前有显著改善;B超显示肝脂肪变也较治疗前明显改善。结论:"降脂膏"脐治疗非酒精性单纯性脂肪肝具有良好的效果。     

自拟降脂通脉饮治疗高脂血症疗效观察

目的:探讨自拟降脂通脉饮治疗高脂血症临床疗效。方法:将60例高脂血症患者分为两组,每组30例,治疗组采用自拟中药降脂通脉饮口服,对照组采用辛伐他汀片口服,比较两组患者治疗后中医症候疗效及血脂指标疗效。比较两组患者治疗前后各项血脂指标和血液流变学指标。结果:治疗组中医症候疗效优于对照组(Z=-1.973,P<0.05);血脂指标疗效优于对照组(Z=-2.599,P<0.05);2组患者治疗后TC、TG、LDL-C较治疗前降低(P<0.05),与对照组比较,治疗组降低明显(P<0.05),HDL-C较治疗前升高(P<0.05),与对照组比较治疗组升高明显(P<0.05);两组患者治疗后血液流变学各项指标均较治疗前改善(P<0.05),治疗组改善情况优于对照组(P<0.05)。结论:自拟中药降脂通脉饮治疗高脂血症疗效确切,安全性高,可在临床推广应用。